Downloads

The final d-LIVER report is available at d-LIVER Final Report, December 2015.

TOP Story on Cordis: d-LIVER: EU project designs home care system for liver patients, October 2014 (download PDF)

d-LIVER Flyer page1 page2 (folder type, low resolution version), update, May 2015

d-LIVER EC project factsheet (A4, 2 pages printable), November 2012

d-LIVER Flyer (A4, 2 pages printable), June 2012

d-LIVER Project Outline Slide, February 2012

Further documents and reports are available for download at The Project – Public Deliverables


Publications:

Philip M. E. Probert, Stephanie K. Meyer, Fouzeyyah Alsaeedi, Andrew A. Axon, Emma A. Fairhall, Karen Wallace, Michelle Charles, Fiona Oakley, Paul A. Jowsey, Peter G. Blaina and Matthew C. Wright
An expandable donor-free supply of functional hepatocytes for toxicology.
Toxicol. Res., 2015,4, 203-222.

Michelle Charles, Karen Wallace, Philip Probert, Fiona Oakley, Matthew Wright,
The glucocorticoid-dependent conversion of the B-13 progenitor cell into hepatocyte-like (B-13/H) cells is dependent on a short exposure to glucocorticoid and epigenetic alterations.
Toxicology Letters, Volume 229, Supplement, 10 September 2014, Pages S141.

Emma Fairhall, Karen Wallace, Matthew Wright
Co-culture of B-13 hepatocyte progenitors with liver myofibroblasts promotes progenitor WNT signalling repression in response to glucocorticoids and enhances their transdifferentiation towards hepatocyte-like cells.
Toxicology Letters, Volume 229, Supplement, 10 September 2014, Pages S138.

Philip Probert, Fiona Oakley, David Tosh, Matthew Wright
Improving expression levels of transporters in progenitor-derived hepatocyte-like (B-13/H) cells.
Toxicology Letters, Volume 229, Supplement, 10 September 2014, Pages S142

Philip Probert, Wasma Alhusainy, Ivonne Rietjens, Matthew Wright
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′ hydroxyestragole to a genotoxic species – An animal donor-free in vitro screen for phase II activated genotoxins
Toxicology Letters, Volume 229, Supplement, 10 September 2014, Pages S47

Philip M. E. Probert, Git W. Chung, Simon J. Cockell, Loranne Agius, Pasquale Mosesso, Steven A. White, Fiona Oakley, Colin D. A. Brown and Matthew C. Wright
Utility of B-13 Progenitor-Derived Hepatocytes in Hepatotoxicity and Genotoxicity Studies.
Toxicol. Sci. (2014) 137 (2): 350-370.

Emma A. Fairhall, Michelle A. Charles, Karen Wallace, Claire J. Schwab, Christine J. Harrison, Marco Richter, Stefan A. Hoffmann, Keith A. Charlton, Katrin Zeilinger and Matthew C. Wright
The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells.
Toxicol. Res., 2013,2, 308-320.

Emma A. Fairhall, Karen Wallace, Steven A. White, Guo C. Huang, James A. Shaw, Sid C. Wright, Keith A. Charlton, Alastair D. Burt and Matthew C. Wright
Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research.
Toxicol. Res., 2013,2, 80-87.

Orr JG, Homer T, Ternent L, Newton J, McNeil CJ, Hudson M, Jones DEJ.
Health related quality of life in people with advanced chronic liver disease.
Journal of Hepatology;61:1158-1165.

Jara M, Malinowski M, Lüttgert K, Schott E, Neuhaus P, Stockmann M.
Prognostic value of enzymatic liver function for the estimation of short-term survival of liver transplant candidates: a prospective study with the LiMAx test.
Transplant International 2014

Malinowski M, Jara M, Lüttgert K, Orr J, Lock J, Schott E, Stockmann M.
Enzymatic Liver Function Capacity Correlates with Disease Severity of Patients with Liver Cirrhosis: A Study with the LiMAx Test.
Digestive Diseases and Sciences 2014:1-9.

Jara M, Bednarsch J, Malinowski M, Luttgert K, Orr J, Puhl G, Seehofer D, Neuhaus P, Stockmann M.
Predictors of quality of life in patients evaluated for liver transplantation.
Clinical transplantation 2014.

Kiefer S, Schäfer M, Bransch M, Brimmers P, Bartolomé D, Baños J, Orr J, Jones D, Jara M, Stockmann M.
A novel personal health system with integrated decision support and guidance for the management of chronic liver disease.

Studies in Health Technology and Informatics, 2014; 205: 83-7.

Orr JG, Morgan CLl, Jenkins-Jones S, Hudson M, Conway P, Radwan A, Currie CJ.
Resource use associated with hepatic encephalopathy in patients with liver disease.
Journal of Hepatology, 60; Suppl 1, S228-229, 2014

Orr JG, Hudson M, Jones DEJ.
Development and Validation of the Newcastle Patient Reported Ascites Measure.
Gut, 63: Suppl 1 A186, 2014

Orr JG, Homer T, Ternent L, Vale L, Hudson M, Jones D.
Associations between healthcare resource ultilisation and health related quality of life in cirrhosis.
Gut, 63: Suppl 1 A88, 2014

Jara M, Orr J, Hüster M, Strisland F, Friso Lock J, Malinowski M, Jones D, Kiefer S, Neuhaus P, Stockmann M.
d-LIVER – A European Commission project to develop a solution for outpatient management of the chronic liver failure patient.
Hepatology International, 7: Suppl 1, S732, 2013


Presentations:

Presentations from the d-LIVER Showcase Workshop, May 2015:
d-LIVER Workshop Overview
, Prof Calum McNeil, Newcastle University, UK
The clinical need for improved management of chronic liver disease, Dr Jim Orr, Newcastle University, UK
d-LIVER Blood Biochemistry Instrument, Stephan Dasen, CSEM, Switzerland
d-LIVER Microfluidic Cartridge, Dr Tobias Schunk, Fraunhofer ICT-IMM, Germany
d-LIVER Sensors Technology, Prof Ciara O’Sullivan, Universitat Rovira i Virgili, Spain
d-LIVER Wearable Devices for Vital Signs Monitoring, Frode Strisland, SINTEF, Norway
d-LIVER Home Monitoring for Hepatic Encephalopathy (HE), Dr Jim Orr, Newcastle University, UK
d-LIVER Bioartificial liver support unit (BAL), Dr Katrin Zeilinger, University Hospital Charité / StemCell Systems GmbH, Germany
d-LIVER Progenitor cells for bioartificial liver, Prof Matt Wright, Newcastle University, UK

Other presentations:

A novel personal health system with integrated decision support and guidance for the management of chronic liver disease, at MIE, September 2014, Istanbul/Turkey.

d-LIVER project overview at Micro Nano Bio Concertation meeting, organised by the European Commission, September 2013, Tyndall, Cork/Ireland

Relative Cost of Hepatocytes at “d-LIVER Review Meeting”, December 2012, Brussels/Belgium

d-Liver – a New Approach for Bridging Therapy to Transplantation of the Chronic Liver Failure Patient and Poster at “24th International Congress of The Transplantation Society”, July 2012, Berlin/Germany

(in German) d-LIVER- Ein neuartiges Behandlungskonzept für Patienten mit chronischer Lebererkrankung at “Biotest Wilsede-Workshop für experimentelle und klinische Lebertransplantation und Hepatologie”, June 2012, Wilsede/Germany


Press Releases and articles:

Press Release in English:  d-LIVER Showcase Workshop, May 2015

Newspaper Article in French: La boîte bleue qui surveillera les malades du foie à domicile (by CSEM), April 2015

Article/interview in Italian: Malattie del fegato, nasce d-LIVER: Live longer, live better, November 2014

Press Release in English: Artificial liver support for the chronically ill (by SINTEF), June 2013

Press Release in Norwegian: Kunstig lever utenfor kroppen (by SINTEF), May 2013

Press Release in German: FhG-IBMT d-LIVER Presseinformation, February 2012