CEA-LETI – France

Commissariat à l’énergie atomique et aux énergies alternatives Laboratoire d’Electronique et de Technologie de l’Information
17, Rue des Martyrs
38054 Grenoble cedex 9, France

d-LIVER Contact:

Marie-Line Cosnier
Tel: +33 4 38 78 65 66
E-mail: marie-line.cosnier(at)cea.fr
Website: www.cea.fr/english_portal/technologies/health_technologies

CEA-Leti’s DTBS unit has several industrial collaborations; in particular a mix research team with BioMerieux in the Commissariat à l’Energie Atomique et aux énergies alternatives is a public research organization. The Laboratoire d’Electronique et de Technologie de l’Information CEA-LETI with more than 1000 employees is a major research centre for Microelectronics, Microtechnologies, Optronics and Instrumentation in Europe. In December 2009, 288 patents were in CEA/LETI’s portfolio in applications of micro-technologies for biology and healthcare amongst the 1574 patents and more than 884 articles in conferences and journals were published. CEA-LETI is a main member in MINATEC initiative and the NanoBio pole of innovation. A dedicated division, DTBS, with a staff of 200 people has been set up for micro-nanotechnology applications in the field of diagnostics, healthcare, life science and environment. At the frontier between micro-nanotechnologies and biology, R&D activities aim to develop highly parallel and miniaturized devices as well as highly integrated portable systems, such as point of care systems. The department knowledge lies in micromachining, microfluidics, surface chemistry, integrated optical detection, electrochemistry in particular in electrochemical grafting, electronics, information processing but more so in their integration in a final system, comprising an instrument a chip and a biological protocol. The DTBS has several industrial collaborations, in particular a mixed research team with BioMerieux in the diagnostic field. CEA-LETI has already accumulated significant microfluidic know-how through several micro-biochip industrial projects. CEA-LETI has also participated in several genotyping industrial projects, in particular with Genset, where high throughput genotyping was implemented in a parallel biphasic microchannel format. Facilities includes a 1000m² clean room and laboratories dedicated to biological microsystem development, Biochip packaging, biology and chemistry as well as specific equipment in biosensor design, manufacturing and characterization .

Previous relevant experience:

Since 1995, achievements at CEA-LETI include: Development of the MICAM technology to manufacture high performance DNA chips on silicone substrate; creation of a joint laboratory with BioMérieux, a French company specialized in in vitro diagnostics; development of a machine for high throughput genotyping with Genset, a French company specialized in genomics; with BioMérieux, successful demonstration of a scanner for high density DNA chips based on the same optical principles as CD readers; start-up of a new company (APIBIO) to industrialize MICAM™ technology; transfer and development program of in-situ DNA chip technology with Yamatake (Japan); launch of Minatec (large facilities for the development of micro and nanotechnologies); Development of various non-invasive (textiles and Kapton) sensors for Na+, K+, Cl ions dosing and accelerometer/magnetometer system for health and sports applications (European projects: Biosensing materials (Biotex), Protection and monitoring of Firefighters (Proetex) and MyHeart); start-up of a new company (MOVEA) to industrialize the accelerometer/magnetometer system; since 2010, CEA-LETI is involved in a new European project dedicated to wearable kidney device (Nephron+), for which non-invasive biosensors are developed.

Marie-Line Cosnier received the M.S. degree in material chemistry from the National College of Chemical Engineering, Clermont-Ferrand, France, in 2000. Since October 2000, she has been with the LETI (Electronics and Information Technology Laboratory) of the French Atomic Energy Commission Micro-Nano Technologies (CEA-LETI-MINATEC), in Grenoble, France, where she has been engaged in projects merging microelectronic and biology in a prospective biotechnology program to develop new tools for high-throughput-screening CMOS-based DNA chip. Since 2005, she has been project leader in different fields. Her research interests include development of biosensors for analytical applications, development for clinicians of in vivo devices for proteomic biomarkers identification, and development for diagnostic industry of point-of-care devices for blood parameters.

Coralie Gallis: PhD in Materials Sciences from Paris 6 University and Physic-Chemistry engineer from Chimie Paris engineering school, Coralie Gallis worked for ASML, a Dutch semiconductor company in the Netherlands as Intelligent Specialist. After this rewarding experience, she joined IMEC in Leuven, Belgium as Business Development Manager for BioMedical electronics. At present, she works for CEA-LETI as Business Development Manager for wearable electronics for biology and healthcare.